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Meera, R.
- HPTLC Analysis and Phytochemical Investigation of Leaves of Euphoria longan
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1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 31-35Abstract
This paper deals with the detailed evaluation of the crude drug by WHO recommended physico-chemical and determinations and authentic phytochemical procedures. The physico-chemical, morphological and histochemical parameters presented in this paper may be proposed as parameters to establish the authenticity of and can possibly help to differentiate the drug from its other species.The presence study demonstrates the presence of some phytochemicals in various extracts and glycosides, saponins , tannins confirmed by HPTLC instrument of Camag system.Keywords
Euphoria longan, HPTLC, Proximate Analysis, Physico-Chemical Investigations.- Synthesis and Biological Screening of Some Novel 4-Thiazolidinone Derivatives
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1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamil Nadu, IN
1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamil Nadu, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 529-535Abstract
A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff’s bases with thiooglycollic acid. The substituted schiff’s bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity.Keywords
Substituted 4-Thiazolidinonnes, Anticonvulsant, Anti Hyperglycemic, Anti Bacterial.- Antibacterial Activity of Crude Extracts and Semi Synthetic Hydrazone Derivatives of Rimelia reticulata
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1 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
3 Department of Biochemistry, K. M. College of Pharmacy, Madurai-625107, Tamilnadu, IN
1 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
3 Department of Biochemistry, K. M. College of Pharmacy, Madurai-625107, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 445-447Abstract
Anti microbial activity of Ether, Acetone Dichloromethane extract and Choloroform extracts and semi synthetic derivatives of Rimelia reticulata were tested against Gram (+) and Gram (-) bacteria strains using zone of inhibition by Agar disc diffusion method.. The bacteria used in test were Gram positive (Staphylococus aureus, Bacillus subtilis and Micrococcus luteus and Gram negative (Escherichia coli, Salmonella typhi and Pseudomonas aureginosa). Moderate antibacterial activity for Ether and Dichloromethane extract, and in Chloroform extract having more than 100% activity and Acetone extract having (90%) activity in Gram (+) organism. In Gram (-) all the extracts having moderate activity (80%). In Semi synthetic derivatives of Rimelia reticulata the Gram (+) and Gram (-) organisms are used. Among the four derivatives 2,4 di nitro hydrazine derivative has more than (100%) activity and 4 nitro phenyl hydrazine, phenyl hydrazine having moderate (80%) activity against Gram (+). In Gram (-) Hydrazine hydrate has shown more than (100% ) and Phenyl hydrazine, 4 nitro phenyl hydrazine having (90%) activity. The standard drug used in this activity is Lincomycin. Based on the current findings it can be concluded that the lichen Rimelia reticulata posses potent antibacterial activity.Keywords
Rimelia reticulata, Antibacterial Activity, Agar Disc Diffusion Method, Crude Extracts, Semi Synthetic Derivatives.- Apoptosis Significance and Molecular Mechanisms-A Review
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Authors
Affiliations
1 Annamalai University, Annamalai Nagar-608002, Tamil Nadu, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
1 Annamalai University, Annamalai Nagar-608002, Tamil Nadu, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 369-375Abstract
Apoptosis, a form of programmed cell death, is a pivotal defense against the occurrence of cancer and is essential to metazoans in maintaining tissue homeostasis. Apoptosis exhibits a distinctive phenotype and involves elimination of potentially deleterious cells. Many diseases have been associated with aberrantly regulated apoptotic cell death, ultimately leading to inhibition of apoptosis and propagation of diseases such as cancer. This review highlights the significance of apoptosis, molecular mechanisms of apoptosis and various methods of causing cell death.Keywords
Apoptosis, Programmed Cell Death, Significance, Mechanisms, Caspases, Bcl-2 Family.- Physio-Chemical Investigation and Wound Healing Activity of Sesame Oil and Formulated Oil
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Authors
Affiliations
1 Shri Sarvajanik Pharmacy College, Mehasana, North Gujarat, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai, IN
3 St. Michael College of Engineering, Kalayarkovil, Tamilnadu, IN
1 Shri Sarvajanik Pharmacy College, Mehasana, North Gujarat, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai, IN
3 St. Michael College of Engineering, Kalayarkovil, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 501-505Abstract
Formulated oil a Siddha formulation was developed using two plant drugs namely Pongamia pinnata seeds and Boerhaavia diffusa ischolar_mains. Preliminary physio chemical screening was performed in both the plants. The wound healing activity was studied with comparison of Sesame oil and Formulated oil by using standard nitro furazone ointment. The methods used were Excision wound model, Incision wound model and Dead space wound model. In excision and incision wound model the formulated oil treated group showed much greater increase in the tensile strength when compared to the control, which was almost similar to that of nitro furazone. In the dead space wound model both the sesame oil and formulated oil produced a significant increase in the wet granuloma tissue weight as well as in the dry weight .Tensile strength was also found to be increased (P<0.001) in both of the oil treated groups.Keywords
Pongamia pinnata, Boerhaavia diffusa, Sesame Oil, Formulated Oil, Wound Healing Activity.- Phyto-Physico Chemical Evaluation, Anti-Inflammatory and Anti Microbial Activities of Aerial Parts of Gmelina asiatica
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Authors
Affiliations
1 Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
3 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
1 Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN
3 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Uthangudi, Madurai-625107, Tamilnadu, IN